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Design Amortization for Bayesian Optimal Experimental Design

AAAI 2023 · Probabilistic and scientific modeling › Uncertainty and Gaussian processes · approach: Simulation-based inference · 2 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
Amortize a conditional variational model across designs rather than train a separate variational model for each designPosterior estimator on the normal (linear) model · Normal (linear) model, 5 predictors, 5 experimental unitswall-clock time: 920s -> 293sHelped
Use the design-amortized model instead of the non-amortized variational formPosterior estimator on the normal (linear) model · 50 randomly generated designsEIG approximation accuracyHelped
Use the learned posterior in VNMC bounds rather than standard NMCGLM model experiments · Normal, logistic, binomial, categorical, and multinomial GLMsEIG bound tightness: 167× fewer samplesHelped
Train the variational posterior with the cheaper posterior estimator, then use it in VNMCDesign-amortized variational posterior · GLM model experimentsVNMC EIG estimation accuracyHelped
Add attention layers to the set encoder instead of using residual layers (ablation)Design-amortized posterior estimator · Linear unknown and binomial models, 5 predictors, prior covariance diagonal 25posterior-estimator lossHelped
Add affine coupling transforms to the conditional base distribution (ablation)Design-amortized posterior estimator · Linear unknown and binomial models, 5 predictors, prior covariance diagonal 25posterior-estimator lossHelped
Increase affine coupling transforms from 4 to 8 (ablation)Design-amortized posterior estimator · Linear unknown and binomial models, 5 predictors, prior covariance diagonal 25posterior-estimator lossNo clear effect
Replace affine coupling transforms with rational quadratic spline transforms (ablation)Design-amortized posterior estimator · Linear unknown and binomial models, 5 predictors, prior covariance diagonal 25posterior-estimator lossNo clear effect

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