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PhysioWave: A Multi-Scale Wavelet-Transformer for Physiological Signal Representation

NeurIPS 2025 · Vision-language and multimodal › Cross-modal learning · approach: Medical multimodal fusion · 1 citations (OpenAlex)

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Proposes PhysioWave, a learnable wavelet-decomposition Transformer with frequency-guided masking, pretrains EMG and ECG foundation models, and fuses them with frozen EEG encoders for multimodal physiological classification.

Problem

Physiological signals (EMG, ECG, EEG) are non-stationary, noisy, and heterogeneous across subjects and devices, and there are few pretrained foundation models for EMG and ECG; standard time-domain/Fourier front-ends and random masking are ill-suited.

Approach

A learnable wavelet front-end (adaptive selection over multiple candidate wavelet bases, soft gating, and cross-scale attention fusion) feeds a masked-patch Transformer; Frequency-guided Masking masks high spectral-energy patches (blended with noise) rather than random patches.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
increase model capacity from Small to LargePhysioWave-ecg · PTB-XLF1: 65.8 -> 66.7Helped
add PhysioWave ECG and EMG branches to EEGPTEEGPT on DEAP · DEAP valenceaccuracy: 79.1% to 85.2% (+6.1%)Helped
add PhysioWave ECG and EMG branches to EEGPTEEGPT on DEAP · DEAP arousalaccuracy: 81.3% to 88.6% (+7.3%)Helped
add PhysioWave EMG and ECG branches to LaBraMLaBraM on MPDB · MPDBaccuracy: 70.4% to 74.9% (+4.5%)Helped
add Frequency-guided Masking (ablation)PhysioWave-emg · EPN-612F1: 92.85 -> 93.67; 0.8%Helped
add large-scale self-supervised pretraining (ablation)PhysioWave-emg · EPN-612F1: 91.57 -> 93.67; 2.1%Helped
add Soft Gate, CAFFN, and Adaptive Wavelet together (ablation)PhysioWave · EPN612Accuracy: 89.88 -> 93.85Helped
use Adaptive Wavelet instead of the fixed-wavelet baseline (ablation)PhysioWave · EPN612Accuracy: +2.35%Helped
use Soft Gate instead of Hard Gate (threshold 0.5) (ablation)PhysioWave · EPN612Accuracy: 92.25 -> 93.85; ↓1.60%Helped
use CrossScale CAFFN instead of Standard FFN (ablation)PhysioWave · EPN612Accuracy: 91.95 -> 93.85; ↓1.90%Helped
use multi-wavelet combination db4+db6+sym4 instead of Random Xavier (ablation)PhysioWave · EPN612 EMGAccuracy: 92.25 -> 93.90; ↑1.65%Helped
use multi-wavelet combination db6+coif4+sym8 instead of Random Xavier (ablation)PhysioWave · Georgia ECGAccuracy: 62.38 -> 64.38; ↑2.00%Helped

Surprising findings

Limitations

Experimental setup

Datasets: MIMIC-IV-ECG NinaPro DB5 EPN-612 UCI EMG PTB-XL CPSC 2018 Chapman-Shaoxing DEAP MPDB Sleep-EDF PPG-DaLiA Georgia ECG

Benchmarks: PTB-XL CPSC 2018 Chapman-Shaoxing NinaPro DB5 EPN-612 UCI EMG DEAP MPDB Sleep-EDF PPG-DaLiA Georgia ECG

Metrics: F1 AUROC accuracy balanced accuracy Cohen's kappa MAE MSE MAPE

Baselines: ECG-Chat MERL MaeFE OpenECG-SimCLR OpenECG-BYOL OpenECG-MAE Moment OTiS EEGPT LaBraM Pulse-PPG BENDR

Builds on: masked autoencoder SpecAugment HuBERT rotary positional embeddings PyWavelets

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