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Anytime-valid, Bayes-assisted, Prediction-Powered Inference

NeurIPS 2025 · Probabilistic and scientific modeling › Molecules and proteins · approach: Prediction-powered and conformal inference · 0 citations (OpenAlex)

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Extends prediction-powered inference to the sequential setting via asymptotic confidence sequences built from KMT strong coupling and the method of mixtures, with Bayes-assisted priors on the prediction rectifier.

Problem

Standard prediction-powered inference (PPI) gives confidence intervals valid only at a fixed labelled sample size, which is inadequate when labelled and unlabelled data arrive over time and conclusions must be drawn continuously.

Approach

Derives anytime-valid PPI confidence sequences by combining asymptotic confidence sequences (almost-sure KMT coupling to i.i.d. Gaussians with Ville's inequality and method of mixtures) with PPI and PPI++ control-variate estimators, and adds a zero-centred prior on the rectifier to tighten intervals when predictions are accurate.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use PPI++ instead of standard PPI as prediction noise increasesPPI confidence sequences · Noisy predictions (σY ∈ {0.1, 0.8, 3})average interval volumeHelped
Use standard PPI rather than classical inferenceconfidence sequences · Noisy predictions with small noiseaverage interval volumeHelped
Use standard PPI rather than classical inferenceconfidence sequences · Noisy predictions with increasing noiseaverage interval volumeHurt
Add a zero-centred prior on the prediction error (ablation)PPI confidence sequences · Biased predictions with small biasaverage interval volumeHelped
Add a zero-centred prior on the prediction error (ablation)PPI confidence sequences · Biased predictions with large absolute biasaverage interval volumeHurt
Use a Gaussian prior rather than Laplace or Student-t (ablation)Bayes-assisted PPI confidence sequences · Biased predictionsaverage interval volumeHurt
Use Laplace or Student-t rather than Gaussian prior (ablation)Bayes-assisted PPI confidence sequences · Biased predictionsaverage interval volumeHelped
Use PPI rather than classical inferenceconfidence sequences · Flights, Forest, and Galaxies mean estimationaverage interval volumeHelped
Add Bayes assistance (ablation)PPI confidence sequences · Flights, Forest, and Galaxies mean estimationaverage interval volumeHelped
Use PPI rather than classical inferenceconfidence sequences · Census linear regression and Healthcare logistic regressionaverage interval volumeHelped
Add Bayes assistance (ablation)PPI confidence sequences · Census linear regression and Healthcare logistic regressionaverage interval volumeHelped
Use PPI rather than classical inferenceconfidence sequences · Genes quantile estimationaverage interval volumeHelped

Surprising findings

Limitations

Experimental setup

Datasets: flights forest galaxies census healthcare genes

Benchmarks: flights forest galaxies census healthcare genes

Metrics: average interval volume cumulative miscoverage rate

Baselines: classical labelled-only confidence sequence standard PPI PPI++

Builds on: prediction-powered inference PPI++ Bayes-assisted PPI asymptotic confidence sequences KMT strong coupling

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