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Synthetic-powered predictive inference

NeurIPS 2025 · Probabilistic and scientific modeling › Molecules and proteins · approach: Prediction-powered and conformal inference · 1 citations (OpenAlex)

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Proposes Synthetic-powered predictive inference (SPI), which uses a score transporter (empirical quantile mapping of real to synthetic nonconformity scores) to calibrate conformal prediction sets with small real calibration sets plus large synthetic data, with finite-sample coverage bounds.

Problem

Conformal prediction yields uninformative or trivial prediction sets when the real labeled calibration set is very small, and synthetic data from a possibly different distribution cannot be naively pooled without breaking coverage.

Approach

A score transporter maps each real calibration/test score to a synthetic score within a probabilistic window derived from order statistics, then runs split conformal on the synthetic scores; coverage bounds hold without assumptions on the synthetic distribution, even when synthetic data depend on the real calibration set.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
use SPI with synthetic images instead of OnlyRealImageNet-1k, Stable Diffusion · ImageNet, marginal and label-conditionalprediction set sizeHelped
use SPI rather than OnlySynthImageNet-1k, Stable Diffusion · ImageNet, marginal and label-conditionalcoverageHelped
use SPI rather than OnlyRealMEPS panel 21 regression · MEPS, age groupscoverageHelped
use SPI-Subset instead of SPI-Whole (ablation)SPI with k-nearest subset selection · ImageNet, label-conditionalprediction set sizeHelped
select a k-nearest synthetic subset instead of using the whole synthetic set (ablation)SPI with k-nearest subset selection · ImageNet, label-conditionalcoverageHelped
use SPI-Subset instead of SPI-Whole (ablation)SPI with k-nearest subset selection · ImageNet, marginalcoverage varianceHurt
use SPI-Subset instead of OnlyReal (ablation)SPI with k-nearest subset selection · ImageNet, marginal and label-conditionalprediction set sizeHelped

Surprising findings

Limitations

Experimental setup

Datasets: ImageNet MEPS

Benchmarks: ImageNet MEPS

Metrics: coverage rate prediction set size prediction interval width

Baselines: OnlyReal split conformal OnlySynth SPI-Whole

Builds on: split conformal prediction adaptive prediction sets conformalized quantile regression label-conditional conformal prediction

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