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BenchX: A Unified Benchmark Framework for Medical Vision-Language Pretraining on Chest X-Rays
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Proposes BenchX, a unified benchmark framework that standardizes data, preprocessing, and task-adaptation protocols to fairly compare nine medical vision-language pretraining methods on chest X-ray classification, segmentation, report generation, and retrieval.
Problem
Existing medical vision-language pretraining (MedVLP) methods are evaluated with differing datasets, preprocessing, and finetuning setups, making fair head-to-head comparison on chest X-ray tasks impossible.
Approach
Pretrain all MedVLP methods on the same frontal MIMIC-CXR training split, standardize preprocessing and hyperparameter grid search, and use unified task heads (linear classifier, frozen-encoder UperNet for segmentation, frozen-encoder R2Gen for report generation) so that differences reflect the pretrained encoder; also shows that classification training tricks (LayerNorm, truncated normal init, di
Key results
- On NIH multi-label classification with 100% data, MRM achieves 85.3 AUROC, the best of the compared methods.
- After applying LN, TNI and DLR training strategies, ConVIRT's NIH AUROC rises from 71.7 to 77.0 and becomes the third-best method, showing configuration sensitivity.
- Averaged across tasks, MRM (avg. rank 2.00) and MGCA-ViT (avg. rank 2.38) rank highest, while M-FLAG ranks last (10.00).
Measured effects reported in the paper
| What was changed | Where | Measured | Effect |
|---|---|---|---|
| Add LN, TNI, and DLR instead of no refinements (ablation) | ConVIRT · NIH classification | AUROC: 71.7 -> 77.0 | Helped |
| Apply DLR (ablation) | ConVIRT · NIH classification | AUROC: 71.7 -> 76.9 | Helped |
| Add LN after DLR (ablation) | ConVIRT · NIH classification | AUROC: 76.9 -> 74.5 | Hurt |
| Apply all refinements (ablation) | MGCA-ViT · NIH classification | AUROC: 78.2 (=) | No clear effect |
| Add LN, TNI, and DLR instead of no refinements (ablation) | MRM · NIH classification | AUROC: 77.9 -> 80.1 | Helped |
| Add LN, TNI, and DLR instead of no refinements (ablation) | REFERS · NIH classification | AUROC: 76.8 -> 75.6 | Hurt |
| Use TNI alone (ablation) | MedVLP classification models · Classification | AUROC | Hurt |
| Use ViT-based rather than ResNet-based encoder | MedCLIP and MGCA · Classification | AUROC or F1 | Helped |
| Use 10% rather than 100% of training data | MedVLP methods · All classification datasets except SIIM | AUROC or F1 | No clear effect |
| Use MedVLP pretraining rather than the from-scratch baseline | Report generation · IU-Xray | BLEU4: 0.133$\pm$0.018 -> 0.148$\pm$0.006 | Helped |
| Use PTUnifier rather than the second-best method | Image-text retrieval · MIMIC 5x200 | H@1: 63.3 -> 78.7 | Helped |
| Use PTUnifier rather than MGCA-ViT | Image-text retrieval · MIMIC 5x200 | P@5: 56.4 -> 38.4 | Hurt |
Surprising findings
- Early method ConVIRT, once finetuned with refined training strategies, matches or beats recent MedVLP methods such as MedCLIP, MedKLIP, and REFERS in several settings.
- Naive linear-head finetuning is suboptimal for nearly all MedVLP methods, and the best training configuration differs per method.
Limitations
- Focuses on frozen or pretrained image-encoder performance on classification and segmentation; cross-modal tasks such as VQA are not covered.
- Only public chest X-ray datasets are used, so generalization to other medical imaging modalities is untested.
- Hyperparameter grid search may be incomplete, so some methods could be suboptimal.
Experimental setup
Datasets: MIMIC-CXR NIH ChestX-ray VinDr-CXR COVIDx CXR-4 SIIM-ACR Pneumothorax RSNA Pneumonia Object CXR TBX11K IU X-ray MIMIC 5x200
Benchmarks: NIH ChestX-ray VinDr-CXR COVIDx CXR-4 SIIM RSNA Pneumonia Object CXR TBX11K IU X-ray MIMIC 5x200
Metrics: AUROC F1 mDice BLEU ROUGE-L METEOR Hit@K Precision@K
Baselines: ConVIRT GLoRIA MedCLIP-R50 MedCLIP-ViT MedKLIP M-FLAG MGCA-R50 MGCA-ViT MRM PTUnifier REFERS
Builds on: ConVIRT GLoRIA MedCLIP MGCA MRM
Closest papers by meaning
- CXReasonBench: A Benchmark for Evaluating Structured Diagnostic Reasoning in Chest X-rays (NeurIPS 2025 · similarity 0.90)
- Rethinking Visual Attribution for Chest X-ray Reasoning in Large Vision Language Models (NeurIPS 2026 · similarity 0.89)
- RadZero: Similarity-Based Cross-Attention for Explainable Vision-Language Alignment in Chest X-ray with Zero-Shot Multi-Task Capability (NeurIPS 2025 · similarity 0.89)
- Unlocking the Power of Spatial and Temporal Information in Medical Multimodal Pre-training (ICML 2024 · similarity 0.88)
- MedSG-Bench: A Benchmark for Medical Image Sequences Grounding (NeurIPS 2025 · similarity 0.87)
- How Do Medical MLLMs Fail? A Study on Visual Grounding in Medical Images (ICLR 2026 · similarity 0.87)
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