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FR²Seg: Continual Segmentation Across Multiple Sites via Fourier Style Replay and Adaptive Consistency Regularization

AAAI 2025 · Continual learning › Domain and prompt-based · approach: Domain-incremental learning with memory · 1 citations (OpenAlex)

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Proposes FR2Seg, a continual multi-site medical segmentation method that replays old-site styles via Fourier amplitude swapping and regularizes domain-invariant parameters with a transferability-weighted Fourier consistency term.

Problem

Continual medical image segmentation across sequentially arriving sites suffers catastrophic forgetting of previous sites and poor generalization to new sites, while privacy and storage limit rehearsal of raw data.

Approach

Uses low-frequency Fourier amplitude as a domain-style representation: stores averaged old-site amplitude styles to synthesize pseudo images with old-site styles (Fourier Style Replay), and identifies domain-invariant parameters via a Fourier style mixup consistency loss, weighted by cross-site transferability measured by cumulative Dice scores.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
add Fourier Style Replay (FSR) (ablation)FR2Seg · Prostate and Fundus, in-order and in-reverseAVG: 85.45 -> 88.30; 75.49 -> 79.68; 84.75 -> 85.18; 84.67 -> 85.38Helped
add Fourier Style Replay (FSR) (ablation)FR2Seg · Prostate and Fundus, in-order and in-reverseBWT: -4.43 -> -1.43; -8.47 -> -3.01; -2.43 -> -1.11; -3.59 -> -3.11Helped
add Fourier Adaptive Consistency Regularization (FACR) (ablation)FR2Seg · Prostate and Fundus, in-order and in-reverseAVG: 81.61 -> 88.30; 74.84 -> 79.68; 84.14 -> 85.18; 85.10 -> 85.38Helped
add Fourier Adaptive Consistency Regularization (FACR) (ablation)FR2Seg · Prostate and Fundus, in-order and in-reverseBWT: -10.59 -> -1.43; -14.63 -> -3.01; -4.01 -> -1.11; -4.77 -> -3.11Helped
add Adaptive Inter-Domain Transferability Weighting (ATW) (ablation)FR2Seg · Prostate and Fundus, in-order and in-reverseAVG: 87.01 -> 88.30; 78.67 -> 79.68; 84.73 -> 85.18; 85.21 -> 85.38Helped
add Adaptive Inter-Domain Transferability Weighting (ATW) (ablation)FR2Seg · Prostate and Fundus, in-order and in-reverseBWT: -1.98 -> -1.43; -5.51 -> -3.01; -1.70 -> -1.11; -4.37 -> -3.11Helped
retain all six previous models instead of only the latest model (ablation)FR2Seg · Prostate, in-orderAVG: 86.74 -> 88.30Helped
retain all six previous models instead of only the latest model (ablation)FR2Seg · Prostate, in-reverseAVG: 78.85 -> 79.68Helped

Limitations

Experimental setup

Datasets: Prostate MRI (NCI-ISBI13, I2CVB, PROMISE12) Fundus (REFUGE, RIM-ONE-r3, Drishti-GS)

Benchmarks: Prostate MRI multi-site sequence Fundus multi-site sequence

Metrics: AVG (seen-domain average Dice) BWT (backward transfer) Dice score

Baselines: FineTune JointTrain LWF POD PLOP MASLR EWC RWalk nnUNet-ViT S3R

Builds on: CISR nnUNet EWC Learning without Forgetting

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