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Real-Time Selection Under General Constraints via Predictive Inference

NeurIPS 2024 · Probabilistic and scientific modeling › Molecules and proteins · approach: Prediction-powered and conformal inference · 0 citations (OpenAlex)

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Proposes II-COS, a real-time sample selection procedure that uses predictive inference (local FDR estimates) to jointly control an individual cost constraint (e.g., FSR) and an interactive pairwise-similarity constraint over a stopping time.

Problem

Online sample selection from a sequential stream of covariates where responses are unobserved, requiring control of individual constraints (FSR or expected cost) and interactive pairwise constraints (e.g., expected similarity/diversity) simultaneously up to an arbitrary stopping time.

Approach

Estimate local FDR from predicted responses via a two-group model and a calibration split, then make sequential accept/reject decisions that check both a running individual-cost ratio and a running pairwise-interaction ratio against thresholds, extending SAST-style online FDR control to general constraints.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use II-COS instead of SASTOnline selection on Candidate dataset · Candidate datasetES (×10^-3): 8.73 -> 0.98Helped
Use II-COS instead of SASTOnline selection on Candidate dataset · Candidate datasetTm: 310 -> 2227Hurt
Use II-COS instead of SASTOnline selection on Income dataset · Income datasetES (×10^-3): 30.90 -> 5.56Helped
Use II-COS instead of SASTOnline selection on Income dataset · Income datasetTm: 1200 -> 2760Hurt
Disable the interactive constraint by setting K = +∞ (ablation)II-COS · Synthetic classificationES: 0.044 -> 0.073Hurt
Disable the individual constraint by setting α = 1 (ablation)II-COS · Synthetic classificationFSR: 0.102 -> 0.849Hurt
Disable the individual constraint by setting α = 1 (ablation)II-COS · Synthetic classificationTm: 628.82 -> 107.79Helped
Vary calibration size from ncal = 200 to ncal = 800 (ablation)II-COS · Synthetic classificationFSR (%): 9.22(0.73) -> 9.36(0.69)No clear effect
Vary calibration size from ncal = 200 to ncal = 800 (ablation)II-COS · Synthetic classificationES (×10^-2): 4.41(0.08) -> 4.40(0.08)No clear effect
Vary calibration size from ncal = 200 to ncal = 800 (ablation)II-COS · Synthetic regressionFSR (%): 5.74(0.18) -> 5.79(0.19)No clear effect
Vary calibration size from ncal = 200 to ncal = 800 (ablation)II-COS · Synthetic regressionES (×10^-2): 1.49(0.03) -> 1.49(0.04)No clear effect

Surprising findings

Limitations

Experimental setup

Datasets: synthetic Gaussian classification and regression data Kaggle recruitment dataset 1994 US Census income dataset

Benchmarks: synthetic classification synthetic regression Kaggle recruitment Census income

Metrics: FSR expected similarity (ES) stopping time Tm expected cost (EC)

Baselines: SAST LOND SAFFRON ADDIS CP (offline conformal p-value selection)

Builds on: SAST (structure-adaptive sequential testing) alpha-investing conformal p-values LOND local FDR

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