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Three-dimensional spike localization and improved motion correction for Neuropixels recordings

NeurIPS 2021 · Point clouds › Point cloud classification · approach: Point cloud detection and tracking · 40 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
Apply Poisson denoising to localization images before motion estimation (ablation)Decentralized registration on Neuropixels 2.0 recording · NP2.0 recording with induced motionmotion estimate jitterHelped
Use proposed 3D localization instead of Hurwitz et al. and center of mass for registrationMotion correction pipeline · NP2.0 recording with induced motionaverage correlation, RMSE, image entropyHelped
Add amplitude-scale feature alpha to x,z location features for clustering (ablation)GMM waveform clustering · NP2.0 spikes in selected z-boxeswaveform cluster separation (qualitative)Helped
Add neural-net denoising and collision suppression before localization (ablation)Spike localization · NP2.0 spikeslocalization quality (qualitative)Helped

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