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Fast Active Set Methods for Online Spike Inference from Calcium Imaging

NeurIPS 2016 · Learning theory and algorithms › Prediction and decision losses · approach: Determinantal point process inference · 43 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
use OASIS instead of generic convex solvers for AR(1) with given lambdaspike inference · simulated AR(1), T=3000computation timeHelped
use OASIS for AR(2) processesspike inference · simulated AR(2)computation timeHelped
use OASIS on real GCaMP6s dataspike inference · GCaMP6s 60 Hztime per trace: 2.37 ± 0.12 s -> 0.101 ± 0.005 sHelped
use OASIS instead of ECOS on zebrafish dataspike inference · 10,000 tracestotal time: 2,818.1 s -> 81.5 sHelped
use hard noise constraint instead of given lambda (ablation)OASIS · simulated AR(1)computation timeHurt
optimize gamma iteratively instead of estimating from autocorrelation (ablation)OASIS · inhomogeneous Poisson simulationcorrelation with true spikes: 0.773 -> 0.869Helped
warm start active set after lambda update (ablation)OASIS · hyperparameter optimizationcomputational costHelped
increase trace length from 3,000 to 30,000 framesOASIS vs convex solvers · simulated tracescomputation timeNo clear effect
use OASIS online instead of convex solversspike inference · memoryRAMHelped

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