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Cowpox: Towards the Immunity of VLM-based Multi-Agent Systems

ICML 2025 · Multi-agent systems and games › LLM agents · approach: LLM multi-agent decision making · 0 citations (OpenAlex)

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Proposes Cowpox, a defense that deploys a few cure-generating agents in a VLM-based multi-agent system so that adversarially optimized cure samples outrank infectious virus samples in RAG retrieval, recovering infected agents and building immunity.

Problem

Infectious jailbreak attacks (AgentSmith) can spread adversarial "virus" samples through the memory banks and RAG retrieval of VLM-based multi-agent systems, compromising the whole system; existing defenses protect individual models rather than the system's recovery dynamics.

Approach

Deploy a small number of defender-controlled "Cowpox" agents that detect suspicious chat outputs with an LLM/VLM inspector and replace the virus in their album with an adversarially optimized benign cure sample that has a higher RAG score than the virus; the cure then spreads like normal content, converting the positive infection feedback loop into a negative one. A differential-equation transmiss

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Add Cowpox Strategy 1 or Strategy 2LLaVA-1.5-7B multi-agent system · Border attack, h=6current infectious rate at r50: 93.75 -> 3.13Helped
Add Cowpox Strategy 1 or Strategy 2LLaVA-1.5-7B multi-agent system · Border attack, h=8cumulative infectious rate at r32: 100.00 -> 91.41; 100.00 -> 92.19Helped
Add Cowpox Strategy 1 or Strategy 2LLaVA-1.5-7B multi-agent system · Pixel attack, epsilon=8/255current infectious rate at r50: 96.88 -> 3.13; 96.88 -> 0.78Helped
Use 3-turn rather than 1-turn output analysisCowpox output analysis module · malicious and benign output classificationACC (%): 84.7 -> 89.1Helped
Use 3-turn rather than 1-turn output analysisCowpox output analysis module · malicious and benign output classificationFPR (%): 2.8 -> 7.9Hurt
Use 3-turn rather than 1-turn output analysisCowpox output analysis module · malicious and benign output classificationFNR (%): 12.5 -> 3.0Helped
Recover the virus sample using Cowpox Strategy 1virus samples from Border attack h=6 · Epoch=10BLEU similarity to benign-sample answers: 0.01 -> 0.8492Helped
Increase album size from 5 to 15 (ablation)Cowpox multi-agent system · transmission dynamicsmaximum current infectious rateHelped
Increase album size from 5 to 15 (ablation)Cowpox multi-agent system · transmission dynamicscumulative infectious rateHurt
Increase agent history length (ablation)Cowpox multi-agent system · transmission dynamicspeak current infectious rateHelped
Increase the number of initially infected agents from 1 to 16 (ablation)Cowpox multi-agent system · transmission dynamicspeak current infectious rateNo clear effect
Increase the number of Cowpox agents from 1 to 16 (ablation)Cowpox multi-agent system · transmission dynamicsmaximum current infectious rateHelped

Surprising findings

Limitations

Experimental setup

Datasets: AdvBench LLaVA-Bench

Benchmarks: AdvBench LLaVA-Bench

Metrics: current infectious rate cumulative infectious rate infectious chance accuracy FPR FNR BLEU CLIP score

Baselines: W/O. Cowpox (no defense) AgentSmith

Builds on: AgentSmith retrieval-augmented generation LLaVA-1.5 CLIP

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