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DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification

CVPR 2022 · Label-efficient and robust learning › Recognition and long-tail · approach: Partial and multi-label learning · 474 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use DTFD-MIL with aggregated feature selection instead of Trans-MILWSI classification · CAMELYON-16 testAUC: 0.906 -> 0.946Helped
Use DTFD-MIL with MaxMinS instead of Trans-MILWSI classification · TCGA lung cancerAUC: 0.949 -> 0.961Helped
Add pseudo-bags and a second-tier MIL over distilled featuresDTFD-MIL · CAMELYON-16AUCHelped
Distill the highest- and lowest-probability instances instead of only the highest-probability instance (ablation)DTFD-MIL · CAMELYON-16 testAUC: 0.907 -> 0.941Helped
Distill the aggregated feature instead of only the highest-probability instance (ablation)DTFD-MIL · CAMELYON-16 testAUC: 0.907 -> 0.946Helped
Distill the highest-attention instance instead of only the highest-probability instance (ablation)DTFD-MIL · CAMELYON-16 testAUC: 0.907 -> 0.945Helped
Distill the highest- and lowest-probability instances instead of only the highest-probability instance (ablation)DTFD-MIL · TCGA lung cancerAUC: 0.919 -> 0.961Helped
Distill the aggregated feature instead of only the highest-probability instance (ablation)DTFD-MIL · TCGA lung cancerAUC: 0.919 -> 0.951Helped
Distill the highest-attention instance instead of only the highest-probability instance (ablation)DTFD-MIL · TCGA lung cancerAUC: 0.919 -> 0.955Helped
Increase the number of pseudo-bags beyond 3 (ablation)Tier-1 MIL · CAMELYON-16AUCHurt
Use MaxS feature distillation rather than another tested distillation strategy (ablation)DTFD-MIL Tier-2 · TCGA lung cancerAUCHurt

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