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Towards Realistic Semi-supervised Medical Image Classification
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Proposes a self-recalibrated semantic training framework for realistic semi-supervised medical image classification with open-set and class-imbalanced unlabeled data, combining informative open-set sample selection, compact semantic clustering, and a dual-balanced classifier.
Problem
Semi-supervised medical image classification in realistic settings where unlabeled data contains unknown (open-set) classes and both labeled and unlabeled data are class-imbalanced, with small inter-class lesion differences.
Approach
Instead of discarding open-set unlabeled samples, select informative ones that share disease-related features with known classes (via prototype-based semantic richness score) and use them as augmentations; add a compact semantic clustering loss and a dual-balanced classifier (similarity pseudo-label regularization plus category-customized thresholds) to handle open-set and imbalance jointly.
Key results
- On ISIC-2019 (γ=5%), the proposed method reaches 69.19% accuracy versus 67.10% for the best closed-set baseline FlexMatch.
- On APTOS-2019 (γ=20%), the method reaches 62.50% vs 61.00% for FlexMatch.
- On HyperKvasir (γ=1%), the method reaches 89.59% vs 88.21% for FlexMatch; ablation shows all three components together give the best results on each dataset.
Measured effects reported in the paper
| What was changed | Where | Measured | Effect |
|---|---|---|---|
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · ISIC-2019, γ=5% | accuracy: 67.10±0.54 -> 69.19±0.34 | Helped |
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · ISIC-2019, γ=10% | accuracy: 70.83±0.12 -> 72.27±0.78 | Helped |
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · ISIC-2019, γ=20% | accuracy: 73.53±0.82 -> 74.90±0.70 | Helped |
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · APTOS-2019, γ=5% | accuracy: 53.67±0.85 -> 56.83±2.95 | Helped |
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · APTOS-2019, γ=10% | accuracy: 57.17±1.70 -> 59.00±1.47 | Helped |
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · APTOS-2019, γ=20% | accuracy: 61.00±0.41 -> 62.50±1.22 | Helped |
| Use the full method rather than FlexMatch | Realistic semi-supervised medical image classification · HyperKvasir, γ=1% | accuracy: 88.21±1.19 -> 89.59±1.29 | Helped |
| Use the full method rather than FixMatch | Realistic semi-supervised medical image classification · HyperKvasir, γ=2% | accuracy: 94.31±0.21 -> 94.41±0.82 | Helped |
| Add informative sample selection (ablation) | Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasir | accuracy: 64.7 -> 67.8; 53.0 -> 54.5; 87.0 -> 87.3 | Helped |
| Add compact semantic clustering alone (ablation) | Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasir | accuracy: 64.7 -> 65.3; 53.0 -> 54.5; 87.0 -> 87.5 | Helped |
| Add dual-balanced classifier alone (ablation) | Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasir | accuracy: 64.7 -> 66.4; 53.0 -> 54.0; 87.0 -> 87.2 | Helped |
| Add informative sample selection and compact semantic clustering (ablation) | Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasir | accuracy: 64.7 -> 67.9; 53.0 -> 55.0; 87.0 -> 87.9 | Helped |
Surprising findings
- Open-set samples in unlabeled data reduce performance for several SSL methods (e.g., Pi-Model drops from 65.8 to 60.8 on ISIC-2019 in open-set vs closed-set setting comparison), and indiscriminately using all open-set samples gives only marginal gains.
Limitations
- Evaluation limited to three medical datasets and a single ResNet-50 backbone.
- Open-set classes in the benchmark are constructed by splitting existing datasets, which may not capture all realistic distribution shifts.
- Improvements over the best baseline are modest (about 1-2 points) with overlapping standard deviations in several settings.
Experimental setup
Datasets: ISIC-2019 APTOS-2019 iAMD-Challenge HyperKvasir
Benchmarks: ISIC-2019 APTOS-2019 HyperKvasir
Metrics: accuracy
Baselines: Pi-Model Mean Teacher MixMatch FixMatch FlexMatch CCSSL OpenMatch MTCF T2T
Builds on: FixMatch OpenMatch FlexMatch CCSSL
Closest papers by meaning
- Systematic Comparison of Semi-supervised and Self-supervised Learning for Medical Image Classification (CVPR 2024 · similarity 0.88)
- ACPL: Anti-Curriculum Pseudo-Labelling for Semi-Supervised Medical Image Classification (CVPR 2022 · similarity 0.88)
- A Semantic Knowledge Complementarity based Decoupling Framework for Semi-supervised Class-imbalanced Medical Image Segmentation (CVPR 2025 · similarity 0.87)
- DuSSS: Dual Semantic Similarity-Supervised Vision-Language Model for Semi-Supervised Medical Image Segmentation (AAAI 2025 · similarity 0.85)
- Combinatorial CNN-Transformer Learning with Manifold Constraints for Semi-supervised Medical Image Segmentation (AAAI 2024 · similarity 0.84)
- SGTC: Semantic-Guided Triplet Co-training for Sparsely Annotated Semi-Supervised Medical Image Segmentation (AAAI 2025 · similarity 0.84)
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