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Towards Realistic Semi-supervised Medical Image Classification

AAAI 2025 · Label-efficient and robust learning › Semi-supervised learning · approach: Confidence-based pseudo-label selection

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Proposes a self-recalibrated semantic training framework for realistic semi-supervised medical image classification with open-set and class-imbalanced unlabeled data, combining informative open-set sample selection, compact semantic clustering, and a dual-balanced classifier.

Problem

Semi-supervised medical image classification in realistic settings where unlabeled data contains unknown (open-set) classes and both labeled and unlabeled data are class-imbalanced, with small inter-class lesion differences.

Approach

Instead of discarding open-set unlabeled samples, select informative ones that share disease-related features with known classes (via prototype-based semantic richness score) and use them as augmentations; add a compact semantic clustering loss and a dual-balanced classifier (similarity pseudo-label regularization plus category-customized thresholds) to handle open-set and imbalance jointly.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · ISIC-2019, γ=5%accuracy: 67.10±0.54 -> 69.19±0.34Helped
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · ISIC-2019, γ=10%accuracy: 70.83±0.12 -> 72.27±0.78Helped
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · ISIC-2019, γ=20%accuracy: 73.53±0.82 -> 74.90±0.70Helped
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · APTOS-2019, γ=5%accuracy: 53.67±0.85 -> 56.83±2.95Helped
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · APTOS-2019, γ=10%accuracy: 57.17±1.70 -> 59.00±1.47Helped
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · APTOS-2019, γ=20%accuracy: 61.00±0.41 -> 62.50±1.22Helped
Use the full method rather than FlexMatchRealistic semi-supervised medical image classification · HyperKvasir, γ=1%accuracy: 88.21±1.19 -> 89.59±1.29Helped
Use the full method rather than FixMatchRealistic semi-supervised medical image classification · HyperKvasir, γ=2%accuracy: 94.31±0.21 -> 94.41±0.82Helped
Add informative sample selection (ablation)Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasiraccuracy: 64.7 -> 67.8; 53.0 -> 54.5; 87.0 -> 87.3Helped
Add compact semantic clustering alone (ablation)Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasiraccuracy: 64.7 -> 65.3; 53.0 -> 54.5; 87.0 -> 87.5Helped
Add dual-balanced classifier alone (ablation)Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasiraccuracy: 64.7 -> 66.4; 53.0 -> 54.0; 87.0 -> 87.2Helped
Add informative sample selection and compact semantic clustering (ablation)Proposed framework · ISIC-2019, APTOS-2019, and HyperKvasiraccuracy: 64.7 -> 67.9; 53.0 -> 55.0; 87.0 -> 87.9Helped

Surprising findings

Limitations

Experimental setup

Datasets: ISIC-2019 APTOS-2019 iAMD-Challenge HyperKvasir

Benchmarks: ISIC-2019 APTOS-2019 HyperKvasir

Metrics: accuracy

Baselines: Pi-Model Mean Teacher MixMatch FixMatch FlexMatch CCSSL OpenMatch MTCF T2T

Builds on: FixMatch OpenMatch FlexMatch CCSSL

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