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Learning to Condition: A Neural Heuristic for Scalable MPE Inference

NeurIPS 2025 · Probabilistic and scientific modeling › Molecules and proteins · approach: Prediction-powered and conformal inference · 0 citations (OpenAlex)

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Proposes learning to condition (L2C), an attention-based neural scorer trained on MPE solver search traces to pick variable-value conditioning decisions that speed up exact and anytime MPE solvers on high-treewidth PGMs.

Problem

MPE inference in probabilistic graphical models is NP-hard, and choosing which variables to condition on (and to which values) strongly affects solver effort and solution quality, while existing heuristics generalize poorly.

Approach

Train an attention-based network with two heads, an optimality head (BCE on oracle MPE solution assignments) and a simplification head (list-ranking loss on inverse solver runtime/node statistics), and use its scores for greedy/beam conditioning or as SCIP branching and node-selection rules.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use L2C-Rank instead of graph-based conditioning decisionsGreedy conditioning for MPE inference with SCIP · 14 high-treewidth PGMslog-likelihood gapHelped
Use L2C-Rank instead of full strong branching for conditioningGreedy conditioning for MPE inference with SCIP · 14 high-treewidth PGMslog-likelihood gapHelped
Use L2C-Rank conditioning before AOBBAOBB MPE inference · 14 high-treewidth PGMsprocessed node countHelped
Use L2C-Rank predictions for branching and node selectionSCIP branch-and-bound · 14 high-treewidth PGMslog-likelihoodHelped
Use beam search rather than a single conditioning sequenceL2C conditioning · 14 high-treewidth PGMslog-likelihood gapNo clear effect

Surprising findings

Limitations

Experimental setup

Datasets: UAI inference competition PGMs (14 high-treewidth binary models)

Benchmarks: UAI inference competition PGMs (BN 12, BN 9, BN 13, Grid 20, BN 65, BN 59, BN 53, BN 49, BN 61, BN 45, Promedas 68, Prom

Metrics: average log-likelihood gap (%) node reduction (%) win counts vs oracle per-decision time

Baselines: graph-based max-degree heuristic full strong branching SCIP default heuristics AOBB

Builds on: AND/OR branch and bound full strong branching SCIP Gibbs sampling

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