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Understanding and Enhancing Mask-Based Pretraining towards Universal Representations

NeurIPS 2025 · Vision-language and multimodal › Human and embodied modeling · approach: Vision-language pretraining · 0 citations (OpenAlex)

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Characterizes mask-based pretraining via test risk of ridge-less linear regression and proposes R²MAE, which samples mask ratios uniformly from a range, improving vision, language, DNA, and single-cell models.

Problem

Mask-based pretraining works across domains with very different optimal masking ratios, and its underlying mechanism and the effect of model size on the optimal mask ratio are not well understood.

Approach

Model feature-level mask autoencoding as minimum-norm (ridge-less) linear regression with random masks, deriving asymptotic test risk that reproduces the sweet-spot masking curves; guided by this, sample the masking ratio uniformly from a range per training example (R²MAE) to learn multi-scale features.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
replace fixed mask ratio 0.75 with a uniformly sampled ratio from 0.6 to 0.9ViT-base MAE · ImageNet classificationTop1 Acc.: 81.97 -> 82.00Helped
replace fixed mask ratio 0.75 with a uniformly sampled ratio from 0.6 to 0.9ViT-base MAE · ImageNet classificationTop5 Acc.: 96.02 -> 96.05Helped
sample mask ratio uniformly from 0.15 to 0.4 instead of using default MLMRoBERTa-Base · GLUE SST-2accuracy: 91.7 -> 91.9Helped
sample mask ratio uniformly from 0.15 to 0.4 instead of using default MLMRoBERTa-Medium · GLUE QNLIaccuracy: 87.1 -> 86.7Hurt
sample masking ratio from a predefined range instead of fixed MLMGPN-MSA · OMIM regulatoryAUPRC: 0.127 -> 0.148Helped
sample masking ratio from a predefined range instead of fixed MAE mask ratio 25%single-cell MLP · SEA-AD brain single-cellAvg performance score: 0.667 -> 0.697Helped
add Dynamic MR to R²MAE (ablation)GPN-MSA · OMIM regulatoryAUPRC: 0.148 -> 0.138Hurt
add CL to R²MAE (ablation)GPN-MSA · OMIM subset class ncRNAAUPRC: 0.136 -> 0.192Helped
add CL to R²MAE (ablation)GPN-MSA · OMIM subset class 3'UTRAUPRC: 0.050 -> 0.058Helped
add CL to R²MAE (ablation)single-cell MLP · SEA-AD brain single-cellAvg performance score: 0.697 -> 0.683Hurt
add Dynamic MR to R²MAE (ablation)single-cell MLP · SEA-AD brain single-cellAvg performance score: 0.697 -> 0.665Hurt
add fixed curriculum CL (k=0) to R²MAE (ablation)single-cell MLP · SEA-AD brain single-cellAvg performance score: 0.697 -> 0.662Hurt

Surprising findings

Limitations

Experimental setup

Datasets: ImageNet FineWeb GLUE MNIST CelebA Clinvar OMIM SEA-AD

Benchmarks: ImageNet GLUE Clinvar OMIM SEA-AD

Metrics: top-1 accuracy top-5 accuracy accuracy F1 AUROC AUPRC Spearman correlation normalized test risk

Baselines: MAE default 0.75 mask ratio MDLM Dynamic MR CL-MAE MLM default 0.15 GPN-MSA scGPT scVI

Builds on: MAE BERT RoBERTa MDLM Dynamic MR

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