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Valid Inference with Imperfect Synthetic Data

NeurIPS 2025 · Probabilistic and scientific modeling › Molecules and proteins · approach: Prediction-powered and conformal inference · 2 citations (OpenAlex)

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Proposes a GMM-based estimator that combines real labeled data with LLM-generated proxy and synthetic samples for valid statistical inference, showing MSE gains when synthetic residuals predict real residuals.

Problem

Combining imperfect LLM-generated synthetic samples with a small human-labeled dataset for statistically valid inference (consistency and proper coverage) in computational social science settings.

Approach

Augment the GMM moment conditions with auxiliary parameters for proxy and synthetic data, where synthetic samples are generated conditioned on individual real texts so their moment residuals correlate with real residuals; the optimal two-step GMM weighting then exploits these cross-moment covariances without a tuning hyperparameter.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Add synthetic-data moments to GMM-ProxyGMM-Proxy · 8 downstream tasksMSE: 8 out of 8Helped
Add synthetic-data moments to GMM-ProxyGMM-Proxy · 8 downstream tasksconfidence interval width: 7 out of 8Helped
Add synthetic-data moments to GMM-ProxyGMM-Proxy · 8 downstream taskscoverageNo clear effect
Add synthetic data using PPI++Synth rather than PPI++ProxyPPI++Proxy · 5 of 8 downstream tasksMSE: 5 tasksNo clear effect
Add synthetic data using PPI++Synth rather than PPI++ProxyPPI++Proxy · 3 of 8 downstream tasksMSE: 3 tasksMixed
Use proxy data and synthetic data alone without the real-data correctionproxy- and synthetic-data estimators · All settingsestimation biasHurt
Use synthetic data whose residuals are independent of real-data residualsGMM-Synth · Asymptotic inferencevarianceNo clear effect
Use synthetic-data residuals predictive of real-data residualsGMM-Synth · Asymptotic inferencevarianceHelped

Surprising findings

Limitations

Experimental setup

Datasets: Stack Exchange and Wikipedia politeness requests climate-related news headlines stance corpus congressional bills texts with DW-NOMINATE scores

Benchmarks: Stack Exchange/Wikipedia politeness (hedging, first-person plural) climate stance headlines congressional bills

Metrics: mean-squared error coverage confidence interval width effective sample size

Baselines: PPI++Proxy PPI++Synth PPI++Synth (Oracle) RePPI GMM-Proxy

Builds on: prediction-powered inference PPI++ RePPI generalized method of moments

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