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Online Feedback Efficient Active Target Discovery in Partially Observable Environments

NeurIPS 2025 · Probabilistic and scientific modeling › Molecules and proteins · approach: Machine learning for physical simulation · 0 citations (OpenAlex)

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Proposes DiffATD, a training-free active target discovery method that uses diffusion-model particles as a belief distribution to balance entropy-based exploration with reward-model-guided exploitation under a fixed measurement budget in partially observable environments.

Problem

Active target discovery in partially observable environments under a limited sampling budget, where existing learned policies need large pre-labeled supervised datasets.

Approach

Uses reverse diffusion particles with Tweedie estimates to form a belief distribution over unobserved cells; scores measurement locations by an entropy-based exploration term plus a reward-weighted expected log-likelihood exploitation term, where the reward model is trained online from measurements and the mix is budget-dependent.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use DiffATD's combined exploration–exploitation policy instead of the strongest listed baselineActive target discovery · DOTA, budgets 200–300SR: 7.01% to 17.23%Helped
Use DiffATD's combined exploration–exploitation policy instead of Greedy-AdaptiveActive target discovery · Coccinella Septempunctata, budgets 100–200SR: 8.48% to 13.86%Helped
Use DiffATD's combined exploration–exploitation policy instead of Greedy-AdaptiveActive target discovery · Skin disease, budgets 150–250SR: 7.92% to 10.18%Helped
Use DiffATD's combined exploration–exploitation policy instead of the best baselineActive target discovery · Bone suppression, budgets 200–300SR: 41.08% to 59.22%Helped
Use DiffATD instead of fully observable FullSEGActive target discovery · Rare targets, budget 300SR: 0.6221 -> 0.8642Helped
Use DiffATD instead of fully observable FullSEGActive target discovery · Vehicles/planes, budget 300SR: 0.8731 -> 0.7309Hurt
Set α=0.2 rather than α=1.0 (stronger exploitation weighting) (ablation)DiffATD · DOTA, budget 200SR: 0.5422 -> 0.5052Hurt
Set α=5.0 rather than α=1.0 (stronger exploration weighting) (ablation)DiffATD · DOTA, budget 200SR: 0.5422 -> 0.4823Hurt
Set α=0.2 rather than α=1.0 (stronger exploitation weighting) (ablation)DiffATD · Skin, budget 200SR: 0.8974 -> 0.8465Hurt
Set α=5.0 rather than α=1.0 (stronger exploration weighting) (ablation)DiffATD · Skin, budget 200SR: 0.8974 -> 0.8782Hurt

Surprising findings

Limitations

Experimental setup

Datasets: DOTA iNaturalist (Coccinella septempunctata) Skin imaging dataset Chest X-ray dataset CelebA

Benchmarks: DOTA iNaturalist Coccinella septempunctata Skin imaging Chest X-ray CelebA

Metrics: success rate (SR)

Baselines: Random Search Max-Ent Greedy-Adaptive FullSEG (SAM) GPT-4o Gemini

Builds on: Tweedie's formula Max-Ent active sampling denoising diffusion models

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