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Amplifying Prominent Representations in Multimodal Learning via Variational Dirichlet Process
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Proposes DPMM, a Dirichlet-process mixture of per-modality Gaussian components trained with stochastic variational inference, to amplify prominent intra-modal features while aligning modalities, and uses the learned marginals to impute missing modalities in EHR/CXR/notes clinical prediction.
Problem
Multimodal fusion must align modality distributions without shrinking modality-specific features, and must handle missing modalities in clinical data where existing alignment and imputation (zeros, means) weaken representations.
Approach
Model each modality's feature distribution as a mixture of multivariate Gaussians whose weights come from a stick-breaking Dirichlet process over modality-component pairs, so the richer-gets-richer property amplifies prominent features; optimize via stochastic variational inference and sample from the learned marginals to impute missing modalities.
Key results
- On MIMIC-IV totally matched IHM, DPMM reaches AUROC 0.826 and AUPR 0.482 versus best baseline DrFuse 0.816/0.446.
- On MIMIC-III partially matched IHM, DPMM reaches AUROC 0.860 vs. 0.854 for DAFT.
- On CMU-MOSI, DPMM achieves MAE 1.09 vs. 1.11 for the best baseline MedFuse.
Measured effects reported in the paper
| What was changed | Where | Measured | Effect |
|---|---|---|---|
| Use DPMM instead of the strongest baseline | MIMIC-III totally matched IHM · MIMIC-III IHM | AUROC: 0.835 -> 0.854 | Helped |
| Use DPMM instead of the strongest baseline | MIMIC-IV totally matched IHM · MIMIC-IV IHM | AUPR: 0.446 -> 0.482 | Helped |
| Use DPMM instead of the strongest baseline | CMU-MOSI · CMU-MOSI | MAE: 1.11 -> 1.09 | Helped |
| Use DPMM instead of the strongest baseline | POM · POM | Accuracy: 0.358 -> 0.359 | Helped |
| add DP alignment (ablation) | DPMM without alignment on MIMIC-IV · MIMIC-IV totally matched IHM | AUROC: 0.809 -> 0.826 | Helped |
| add gradient-preserving sampling (ablation) | DPMM without GPS on MIMIC-IV · MIMIC-IV totally matched IHM | AUROC: 0.855 -> 0.860 | Helped |
| add the fusion module (ablation) | DPMM without fusion on MIMIC-IV · MIMIC-IV totally matched IHM | AUROC: 0.857 -> 0.860 | Helped |
| use DP alignment loss instead of cosine loss (ablation) | MIMIC-IV DPMM alignment · MIMIC-IV totally matched IHM | AUROC: 0.816 -> 0.826 | Helped |
| use DP alignment loss instead of KL loss (ablation) | MIMIC-IV DPMM alignment · MIMIC-IV totally matched IHM | AUROC: 0.820 -> 0.826 | Helped |
| add cross-modal alignment to DP amplification (ablation) | MIMIC-IV DPMM · MIMIC-IV totally matched IHM | AUROC: 0.816 -> 0.826 | Helped |
| use DP mixture weights instead of learnable weights (ablation) | MIMIC-IV DPMM · MIMIC-IV partially matched IHM | AUROC: 0.855 -> 0.860 | Helped |
| increase the maximum mixture count K (ablation) | DPMM · MIMIC-IV READM | AUROC | Helped |
Surprising findings
- Learnable mixture weights in place of DP weights gave lower performance (e.g., 0.821 vs 0.826 AUROC on totally matched IHM).
- Amplification alone already improves over the w/o DP baseline, but adding alignment gives further gains.
Limitations
- Uses diagonal covariance only; full covariance and Wishart priors are left for future work.
- Hierarchical DP variants not explored.
- Training time is higher than most baselines.
Experimental setup
Datasets: MIMIC-III MIMIC-IV MIMIC-CXR MIMIC-III NOTE CMU-MOSI POM
Benchmarks: MIMIC-III MIMIC-IV CMU-MOSI POM
Metrics: AUROC AUPR F1 MAE accuracy Corr
Baselines: MMTM DAFT Unified MedFuse DrFuse LMF TFN CLIP ALIGN CoMM PSA LSMT
Builds on: DrFuse MedFuse Dirichlet process mixture model stick-breaking construction
Closest papers by meaning
- MSP: Modality Self-Play for Training Multimodal LLMs Without Paired Cross-Modal Data (NeurIPS 2026 · similarity 0.89)
- Beyond Modality Fusion: Deep Ensembles for Multimodal Classification (NeurIPS 2026 · similarity 0.88)
- Fusion or Confusion? Multimodal Complexity Is Not All You Need (NeurIPS 2026 · similarity 0.88)
- Aligning Multimodal Representations through an Information Bottleneck (ICML 2025 · similarity 0.87)
- On the Value of Cross-Modal Misalignment in Multimodal Representation Learning (NeurIPS 2025 · similarity 0.87)
- When to Align, When to Predict: A Phase Diagram for Multimodal Learning (NeurIPS 2026 · similarity 0.87)
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