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Amplifying Prominent Representations in Multimodal Learning via Variational Dirichlet Process

NeurIPS 2025 · Vision-language and multimodal › Cross-modal learning · approach: Multimodal fusion with missing modalities · 0 citations (OpenAlex)

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Proposes DPMM, a Dirichlet-process mixture of per-modality Gaussian components trained with stochastic variational inference, to amplify prominent intra-modal features while aligning modalities, and uses the learned marginals to impute missing modalities in EHR/CXR/notes clinical prediction.

Problem

Multimodal fusion must align modality distributions without shrinking modality-specific features, and must handle missing modalities in clinical data where existing alignment and imputation (zeros, means) weaken representations.

Approach

Model each modality's feature distribution as a mixture of multivariate Gaussians whose weights come from a stick-breaking Dirichlet process over modality-component pairs, so the richer-gets-richer property amplifies prominent features; optimize via stochastic variational inference and sample from the learned marginals to impute missing modalities.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use DPMM instead of the strongest baselineMIMIC-III totally matched IHM · MIMIC-III IHMAUROC: 0.835 -> 0.854Helped
Use DPMM instead of the strongest baselineMIMIC-IV totally matched IHM · MIMIC-IV IHMAUPR: 0.446 -> 0.482Helped
Use DPMM instead of the strongest baselineCMU-MOSI · CMU-MOSIMAE: 1.11 -> 1.09Helped
Use DPMM instead of the strongest baselinePOM · POMAccuracy: 0.358 -> 0.359Helped
add DP alignment (ablation)DPMM without alignment on MIMIC-IV · MIMIC-IV totally matched IHMAUROC: 0.809 -> 0.826Helped
add gradient-preserving sampling (ablation)DPMM without GPS on MIMIC-IV · MIMIC-IV totally matched IHMAUROC: 0.855 -> 0.860Helped
add the fusion module (ablation)DPMM without fusion on MIMIC-IV · MIMIC-IV totally matched IHMAUROC: 0.857 -> 0.860Helped
use DP alignment loss instead of cosine loss (ablation)MIMIC-IV DPMM alignment · MIMIC-IV totally matched IHMAUROC: 0.816 -> 0.826Helped
use DP alignment loss instead of KL loss (ablation)MIMIC-IV DPMM alignment · MIMIC-IV totally matched IHMAUROC: 0.820 -> 0.826Helped
add cross-modal alignment to DP amplification (ablation)MIMIC-IV DPMM · MIMIC-IV totally matched IHMAUROC: 0.816 -> 0.826Helped
use DP mixture weights instead of learnable weights (ablation)MIMIC-IV DPMM · MIMIC-IV partially matched IHMAUROC: 0.855 -> 0.860Helped
increase the maximum mixture count K (ablation)DPMM · MIMIC-IV READMAUROCHelped

Surprising findings

Limitations

Experimental setup

Datasets: MIMIC-III MIMIC-IV MIMIC-CXR MIMIC-III NOTE CMU-MOSI POM

Benchmarks: MIMIC-III MIMIC-IV CMU-MOSI POM

Metrics: AUROC AUPR F1 MAE accuracy Corr

Baselines: MMTM DAFT Unified MedFuse DrFuse LMF TFN CLIP ALIGN CoMM PSA LSMT

Builds on: DrFuse MedFuse Dirichlet process mixture model stick-breaking construction

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