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Efficient Randomized Experiments Using Foundation Models

NeurIPS 2025 · Probabilistic and scientific modeling › Molecules and proteins · approach: Statistical analysis of ML practice · 1 citations (OpenAlex)

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Proposes Hybrid AIPW (H-AIPW), which optimally combines the standard AIPW estimator from experimental data with AIPW estimators that plug in predictions from multiple LLMs, to gain precision while keeping valid inference.

Problem

Randomized experiments are costly and imprecise, while in silico experiments using foundation model predictions can yield invalid inference if the predictions are biased. The goal is to use foundation model predictions to improve ATE precision without losing validity or risking higher variance than

Approach

Treat each foundation-model outcome regression as an AIPW estimator and combine them, together with the standard experimental-data AIPW, via variance-minimizing convex weights estimated from the empirical covariance of influence functions. The combined estimator is asymptotically normal and has variance no larger than any component, even when the models are arbitrarily biased.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Integrate multiple foundation-model predictions with standard AIPWH-AIPW · Eight randomized experiments, n=100 and n=200variance: 11.72 -> 10.39Helped
Replace one foundation model with an ensemble of 5 to 7 models (ablation)H-AIPW · Study by [cite], 50 samplesvariance: approximately 6% to nearly 12%; around 16%Helped
Increase the ensemble from 1 to 7 foundation models (ablation)H-AIPW · Study by [cite], 50 samplescoverage: 2%–4%Hurt
Average predictions over more inference-time prompts (ablation)H-AIPW · Three randomized studies using GPT-4ovarianceHelped
Use larger language models rather than smaller models (ablation)H-AIPW · LLM prediction evaluation across randomized experimentsMSEHelped

Surprising findings

Limitations

Experimental setup

Datasets: TESS survey experiments (eight studies from Melin et al. 2022, Silverman et al. 2022, Kennedy et al. 2020, Fahey et al.

Benchmarks: TESS survey experiments (eight studies, subsampled at n=100 and n=200)

Metrics: variance (scaled, averaged over subsampling repetitions) coverage probability at 95% nominal level mean squared error of LLM predictions

Baselines: difference in means standard AIPW (linear) AIPW (boosting) PPCT PROCOVA

Builds on: augmented inverse probability weighting prediction-powered inference PPI++ PPCT PROCOVA

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