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ZeroSep: Separate Anything in Audio with Zero Training

NeurIPS 2025 · Image generation › Autoregressive and latent generation · approach: Diffusion audio synthesis · 0 citations (OpenAlex)

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Shows that a pre-trained text-guided audio diffusion model (AudioLDM/AudioLDM2/Tango) can perform zero-shot text-queried source separation via DDIM/DDPM latent inversion of the mixture followed by text-conditioned denoising with classifier-free guidance weight 1.

Problem

Audio source separation normally requires large task-specific supervised training data and struggles with open-set real-world acoustic scenes; the paper asks whether pre-trained text-guided audio diffusion models can separate sources without any training.

Approach

Invert the mixed audio into a diffusion latent space (DDIM/DDPM inversion with a null or other-source prompt), then denoise with a text prompt describing the target source and classifier-free guidance weight omega=1, which removes the unconditional term and isolates the target; omega>1 causes generation rather than separation.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
use ZeroSep instead of FlowSepMUSIC separation · MUSIC testFAD: 0.402 -> 0.377Helped
use ZeroSep instead of FlowSepMUSIC separation · MUSIC testC-A: 0.564 -> 0.615Helped
use ZeroSep instead of FlowSepAVE separation · AVE testFAD: 0.258 -> 0.269Hurt
use ZeroSep instead of FlowSepAVE separation · AVE testLPAPS: 4.719 -> 4.537Helped
replace the target reverse prompt with a random prompt (ablation)ZeroSep on MUSIC · MUSIC testC-A: 0.615 -> 0.363Hurt
replace the target reverse prompt with a random prompt (ablation)ZeroSep on AVE · AVE testFAD: 0.269 -> 0.325Hurt
replace the null inversion prompt with a non-target source prompt (ablation)ZeroSep on MUSIC · MUSIC testLPAPS: 4.669 -> 4.547Helped
replace the null inversion prompt with a non-target source prompt (ablation)ZeroSep on MUSIC · MUSIC testFAD: 0.377 -> 0.454Hurt
replace the null inversion prompt with a non-target source prompt (ablation)ZeroSep on AVE · AVE testC-A: 0.442 -> 0.496Helped
replace the null inversion prompt with a non-target source prompt (ablation)ZeroSep on AVE · AVE testFAD: 0.269 -> 0.321Hurt
increase classifier-free guidance from 0 to 1 (ablation)ZeroSep · separation evaluationLPAPSHelped
increase classifier-free guidance above 1 (ablation)ZeroSep · separation evaluationLPAPSHurt

Surprising findings

Limitations

Experimental setup

Datasets: AVE MUSIC AudioCap

Benchmarks: MUSIC AVE

Metrics: FAD LPAPS CLAP-A CLAP-T SDR SIR SAR

Baselines: LASS-Net AudioSep FlowSep NMF-MFCC AudioEdit

Builds on: DDIM DDPM inversion AudioLDM AudioLDM2 Tango

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