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Iterative Foundation Model Fine-Tuning on Multiple Rewards

NeurIPS 2025 · Reinforcement learning › RL from feedback · approach: RL fine-tuning of generative models · 0 citations (OpenAlex)

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Proposes IterativeRS, which fine-tunes foundation models with PPO on each reward separately and periodically merges expert policies (generalizing MORLHF and Rewarded Soups), with a convergence analysis for convex losses and experiments on molecules, DNA, and summarization.

Problem

Fine-tuning foundation models on multiple, possibly conflicting reward objectives, where single-reward scalarization yields high variance across objectives and naive expert merging can degrade performance.

Approach

Fine-tune one expert per objective but periodically (every m steps) merge experts into a shared policy that restarts the next round of objective-specific fine-tuning, optionally updating only a random subset of M objectives per round; this interpolates between reward combining (m=1) and Rewarded Soups (m=T).

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use iterative fine-tuning and merging instead of RSMulti-objective molecule generation with MolGPT-2 · Small molecule generation (QM9)Avg Reward: 1.3062 -> 1.4017Helped
Use iterative fine-tuning and merging instead of RSMulti-objective molecule generation with MolGPT-2 · Small molecule generation (QM9)ICV: 4.2674 -> 3.5854Hurt
Use iterative fine-tuning and merging instead of RiCMulti-objective DNA generation with DNAGPT-2 · DNA sequence generationAvg Reward: 0.5842 -> 0.5927Helped
Use iterative fine-tuning and merging instead of RSMulti-objective DNA generation with DNAGPT-2 · DNA sequence generationICV: 3.8235 -> 3.8310Helped
Use iterative fine-tuning and merging instead of RSMulti-objective Reddit summarization with Llama-3.2-3B-Instruct · Reddit summarizationAvg Score: 0.4732 -> 0.4849Helped
Use iterative fine-tuning and merging instead of RSMulti-objective Reddit summarization with Llama-3.2-3B-Instruct · Reddit summarizationICV: 4.5870 -> 4.9134Helped
Use iterative fine-tuning and merging instead of RSMulti-objective DNA generation with DNAGPT-2 using RLOO · DNA sequence generation (RLOO)Avg Reward: 0.5812 -> 0.5826Helped
Use selective merging weights rather than uniform fixed merging weights (ablation)IterativeRS on DNA sequence generation · DNA sequence generation (RLOO)Avg RewardNo clear effect

Surprising findings

Limitations

Experimental setup

Datasets: MOSES QM9 MPRA Reddit Summary dataset

Benchmarks: QM9 (PAMNet-evaluated molecules) MPRA (Malinois-evaluated DNA sequences) Reddit post summarization

Metrics: average reward per objective average reward across objectives ICV (inverse coefficient of variation) ROUGE Avg Score

Baselines: MORLHF Rewarded Soups Rewards-in-Context

Builds on: Rewarded Soups PPO MORLHF Rewards-in-Context

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