Research map / Probabilistic and scientific modeling / Dynamical systems
Uncover Governing Law of Pathology Propagation Mechanism Through A Mean-Field Game
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Proposes a mean-field game model to uncover the governing law of tau propagation across cortex and its interaction with amyloid-beta in Alzheimer's disease.
Problem
Quantitative analysis of cortical tau propagation pathways and their interaction with amyloid-beta plaque cascades in Alzheimer's disease is lacking because pathology spreading flows are hard to image in vivo.
Approach
Models tau spreading across the cortex as a mean-field game to infer the governing mechanism of propagation and its coupling with amyloid-beta, rather than relying on direct in vivo flow imaging.
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