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Uncover Governing Law of Pathology Propagation Mechanism Through A Mean-Field Game

NeurIPS 2025 · Probabilistic and scientific modeling › Dynamical systems · approach: Latent dynamics models · 0 citations (OpenAlex)

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Proposes a mean-field game model to uncover the governing law of tau propagation across cortex and its interaction with amyloid-beta in Alzheimer's disease.

Problem

Quantitative analysis of cortical tau propagation pathways and their interaction with amyloid-beta plaque cascades in Alzheimer's disease is lacking because pathology spreading flows are hard to image in vivo.

Approach

Models tau spreading across the cortex as a mean-field game to infer the governing mechanism of propagation and its coupling with amyloid-beta, rather than relying on direct in vivo flow imaging.

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