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Contrastive learning of global and local features for medical image segmentation with limited annotations

NeurIPS 2020 · Label-efficient and robust learning › Semi-supervised learning · approach: Semi-supervised medical segmentation · 86 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use corresponding-volume slice partitions to define global contrastive pairs (G^D) rather than random pairs (G^R) (ablation)Global contrastive pre-training · ACDC, Prostate, MMWHSDSC: 0.631 -> 0.691; 0.521 -> 0.579; 0.500 -> 0.553 (|X_tr|=1)Helped
Add positive pairs across corresponding partitions of different volumes (G^D instead of G^D-) (ablation)Global contrastive pre-training · Across the 9 dataset and training-volume settingsDSCMixed
Add local contrastive decoder pre-training using L^R (ablation)G^R global pre-training · ACDC, Prostate, MMWHSDSC: 0.631 -> 0.668; 0.521 -> 0.557; 0.500 -> 0.528 (|X_tr|=1)Helped
Use corresponding-volume local-region positives (L^D) instead of random local sampling (L^R) (ablation)Local contrastive decoder pre-training · Across the 9 dataset and training-volume settingsDSCMixed
Increase global pre-training batch size from 40 to 450 (ablation)G^D encoder pre-training · ACDC, |X_tr|=1DSC: 0.691 -> 0.668Hurt
Use 6 rather than 4 partitions per volume (ablation)G^D encoder pre-training · ACDCDSC: 0.691 -> 0.652; 0.789 -> 0.760; 0.870 -> 0.859Hurt
Increase local region size from 1×1 to 3×3 (ablation)Local contrastive decoder pre-training · Prostate, MMWHSDSC: Prostate: 0.554 -> 0.567 and 0.614 -> 0.607; MMWHS: 0.559 -> 0.574 and 0.674 -> 0.681Mixed
Pre-train all 5 decoder blocks rather than a shorter decoder (ablation)Local contrastive decoder pre-training · ACDCDSC: 0.703 -> 0.690 (3×3 regions, |X_tr|=1; d3 -> d5)Hurt
Jointly optimize global and local losses rather than use stage-wise training (ablation)Proposed pre-training · ACDCDSC: 0.725 -> 0.634 (|X_tr|=1); 0.789 -> 0.741 (|X_tr|=2)Hurt
Combine proposed pre-training with MixupProposed initialization · ACDC, Prostate, MMWHSDSC: 0.725 -> 0.757; 0.579 -> 0.588; 0.569 -> 0.617 (|X_tr|=1)Helped
Combine proposed pre-training with self-trainingProposed initialization · Prostate, MMWHSDSC: 0.579 -> 0.607; 0.569 -> 0.647 (|X_tr|=1)Helped
Use proposed contrastive initialization instead of random initializationUNet segmentation · ACDC, Prostate, MMWHSDSC: 0.614 -> 0.725; 0.489 -> 0.579; 0.451 -> 0.569 (|X_tr|=1)Helped

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