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High resolution neural connectivity from incomplete tracing data using nonnegative spline regression

NeurIPS 2016 · Learning theory and algorithms › Matrix and tensor methods · approach: Geometry of low-rank and SPD structure · 4 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
replace regional homogeneous model with smooth voxel modelconnectivity estimator · Allen visual cortex, voxel spacecross-validation MSErel: 107% -> 33%Helped
replace regional model with voxel modelconnectivity estimator · Allen visual cortex, regional spacecross-validation MSErel: 48% -> 16%Helped
replace regional model with voxel modelconnectivity estimator · Allen visual cortex, voxel spacetraining MSErel: 70% -> 10%Helped
replace regional model with voxel modelconnectivity estimator · Allen visual cortex, regional spacetraining MSErel: 6.8% -> 2.3%Helped
remove matrix completion term P_Omega (fit zeros in injection site) (ablation)nonnegative spline regression (P1) · 1-D synthetic testreconstruction qualityHurt
remove smoothing penalty (lambda = 0) (ablation)nonnegative spline regression (P1) · 1-D synthetic testreconstruction qualityHurt
use low rank factorization r=20 instead of full ranknonnegative spline regression · 1-D synthetic testrelative error: 11.1% -> 9.6%Helped
low rank r=160 instead of full ranknonnegative spline regression · Allen visual cortexrelative difference from full solution: 13%No clear effect

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