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Generalized Correspondence-LDA Models (GC-LDA) for Identifying Functional Regions in the Brain

NeurIPS 2016 · Probabilistic and scientific modeling › Dynamical systems · approach: Functional connectivity modeling · 13 citations (OpenAlex)

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Measured effects reported in the paper

What was changedWhereMeasuredEffect
Set gamma > 0 (non-zero correspondence smoothing) instead of gamma = 0 (ablation)GC-LDA (all three variants) · Neurosynth held-out dataheld-out log-likelihood (activation + word tokens)Helped
Increase gamma from 0.01 to larger values for activation-only prediction (ablation)GC-LDA (all three variants) · Neurosynth held-out dataheld-out log-likelihood (activation tokens only)Helped
Set gamma in the 0.01 to 0.1 range instead of very small or very large values (ablation)GC-LDA (all three variants) · Neurosynth held-out dataheld-out log-likelihood (word tokens and overall)Mixed
Replace single multivariate Gaussian spatial distribution with a mixture of two Gaussians (unconstrained subregions) (ablation)GC-LDA spatial representation · Neurosynth held-out dataheld-out total log-likelihoodHelped
Replace single Gaussian with two symmetric constrained Gaussian subregions (ablation)GC-LDA spatial representation · Neurosynth held-out dataheld-out word-token log-likelihoodHurt
Constrain subregion means to be symmetric about the midline (constrained vs unconstrained subregions) (ablation)GC-LDA subregions model · Neurosynth held-out dataheld-out activation-token log-likelihoodHelped
Constrain subregion means to be symmetric about the midline (constrained vs unconstrained subregions) (ablation)GC-LDA subregions model · Neurosynth held-out dataheld-out word-token log-likelihoodHurt
Constrain subregion means to be symmetric about the midline (constrained vs unconstrained subregions) (ablation)GC-LDA subregions model · Neurosynth held-out dataheld-out total log-likelihoodNo clear effect
Use the constrained subregions model to get interpretable hemispheric lateralization weightsGC-LDA constrained subregions · Neurosynth topics (qualitative)qualitative recovery of known lateralizationHelped

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