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Robustness of Deep Learning for Accelerated MRI: Benefits of Diverse Training Data

ICML 2024 · Label-efficient and robust learning › Recognition and long-tail · approach: Data augmentation and generalization bias · 4 citations (OpenAlex)

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Shows that training one accelerated-MRI reconstruction model on diverse data (multiple anatomies, contrasts, field strengths, ~413k slices from 13 datasets) matches separate per-distribution models in-distribution and improves out-of-distribution robustness, while noting distributional overfitting under long training.

Problem

Deep learning MRI reconstruction models degrade under distribution shifts (anatomy, contrast, scanner, field strength), and it is unclear whether training on diverse data compromises in-distribution performance or helps robustness.

Approach

Training a single model on a union of diverse MRI distributions matches separately trained models in-distribution and yields effective robustness (above the in-distribution vs. out-of-distribution trend line), with robustness correlated with CLIP-feature nearest-neighbor similarity between training and test sets; early stopping mitigates distributional overfitting.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Train on a diverse collection of datasets instead of fastMRI aloneU-net · Out-of-distribution MRI datasets (CC-359 sagittal, NYU, Stanford 2D, M4Raw GRE)LPIPS/DISTS: CC-359 sagittal: 0.294/0.185 -> 0.247/0.149; NYU: 0.226/0.128 -> 0.221/0.128; Stanford 2D: 0.260/0.163 -> 0.257/0.154; MHelped
Train on a diverse collection of datasets instead of fastMRI aloneViT · Out-of-distribution MRI datasets (CC-359 sagittal, NYU, Stanford 2D, M4Raw GRE)LPIPS/DISTS: CC-359 sagittal: 0.264/0.168 -> 0.228/0.149; NYU: 0.254/0.150 -> 0.219/0.128; Stanford 2D: 0.258/0.168 -> 0.243/0.154; MHelped
Train jointly on 2-fold, 4-fold, 8-fold, and 16-fold accelerationU-net · fastMRI PDFS knee, 3-fold accelerationSSIM: 0.906 -> 0.912Helped
Train jointly on 2-fold, 4-fold, 8-fold, and 16-fold accelerationU-net · fastMRI PDFS knee, 2-fold, 4-fold, 8-fold, and 16-fold accelerationSSIM: 2-fold: 0.945 -> 0.944; 4-fold: 0.903 -> 0.902; 8-fold: 0.867 -> 0.866; 16-fold: 0.828 -> 0.829No clear effect
Use one regularization weight across distributions rather than tuning it separatelyWavelet l1 least-squares · fastMRI knee, PD Knee Skyra 3.0T and PDFS Knee Aera 1.5TSSIM: P: 0.788 -> 0.792; Q: 0.602 -> 0.609Mixed
Train on diverse healthy-subject data without pathology examplesU-net, ViT, and VarNet · fastMRI brain pathology regionsSSIMNo clear effect
Stop training early rather than continue to 60 epochsU-net, ViT, and VarNet · Out-of-distribution MRI, including fastMRI T2 brain to fastMRI kneeSSIMHelped
Use SGD instead of Adam (ablation)U-net · fastMRI brain and fastMRI kneeSSIMNo clear effect
Train jointly on P and Q rather than train separate models on each distributionU-net, ViT, and VarNet · fastMRI anatomy, contrast, and magnetic-field distributionsSSIMNo clear effect
Train one model on skewed P+Q data, with P about 10 times smaller than QU-net · fastMRI anatomy, contrast, and magnetic-field distributionsSSIMNo clear effect

Surprising findings

Limitations

Experimental setup

Datasets: fastMRI knee fastMRI brain fastMRI prostate M4Raw SKM-TEA Stanford 3D Stanford 2D 7T database CC-359 NYU data fastMRI+

Benchmarks: fastMRI knee validation fastMRI brain test CC-359 sagittal Stanford 2D M4Raw GRE NYU data

Metrics: SSIM LPIPS DISTS effective robustness

Baselines: U-net ViT end-to-end VarNet l1-regularized least squares

Builds on: fastMRI CLIP effective robustness

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