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dFLMoE: Decentralized Federated Learning via Mixture of Experts for Medical Data Analysis

CVPR 2025 · Federated learning and privacy › Personalized and heterogeneous FL · approach: Federated medical and multimodal learning · 5 citations (OpenAlex)

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Proposes dFLMoE, a decentralized federated learning framework where clients exchange lightweight head models directly and fuse them with a client-specific attention-based mixture of experts for medical data analysis.

Problem

Centralized federated learning in medical settings causes knowledge damage during server-side aggregation and depends on the stability of a central server, while existing decentralized FL work mostly addresses security rather than the algorithm.

Approach

Clients share only lightweight head models peer-to-peer (no central aggregation), and each client treats local and received heads as experts combined by a cross-attention mixture of experts with a feature space transform, enabling client-specific fusion that tolerates model heterogeneity.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
use decentralized dFLMoE instead of MH-pFLIDBreaKHis classification, homogeneous models · BreaKHis classification, AverageACC: 0.8083 -> 0.8319Helped
use decentralized dFLMoE instead of MH-pFLIDBreaKHis classification, heterogeneous models · BreaKHis classification, AverageACC: 0.8583 -> 0.8880Helped
use dFLMoE instead of FedRepBreaKHis super-resolution, homogeneous models · BreaKHis super-resolution, AveragePSNR: 25.49 -> 28.61Helped
use dFLMoE instead of Only Local TrainingBreaKHis super-resolution, heterogeneous models · BreaKHis super-resolution, AveragePSNR: 25.43 -> 29.30Helped
use dFLMoE instead of MH-pFLIDSleep-EDF homogeneous models · Sleep-EDF, AverageACC: 0.8700 -> 0.9041Helped
use dFLMoE instead of MH-pFLIDSleep-EDF heterogeneous models · Sleep-EDF, AverageACC: 0.8801 -> 0.9136Helped
use dFLMoE instead of MH-pFLIDBreaKHis breast cancer classification · BreaKHis breast cancer classification, AverageACC: 0.9016 -> 0.9163Helped
use dFLMoE instead of MH-pFLIDODIR-5K ocular disease recognition · ODIR-5K, AverageACC: 0.7310 -> 0.7647Helped
use dFLMoE instead of LC-FedPolyp segmentation with homogeneous models · Polyp segmentation, AverageDice: 0.6772 -> 0.7813Helped
use dFLMoE instead of MH-pFLIDPolyp segmentation with heterogeneous models · Polyp segmentation, AverageDice: 0.7671 -> 0.7806Helped
add the designed MoE module (ablation)dFLMoE · Sleep-EDF time-series classificationACC: 0.8731 -> 0.9041Helped
add feature space transform (ablation)dFLMoE · Sleep-EDF time-series classificationACC: 0.8812 -> 0.9041Helped

Surprising findings

Limitations

Experimental setup

Datasets: BreaKHis Sleep-EDF ODIR-5K Polyp segmentation dataset (four centers)

Benchmarks: BreaKHis Sleep-EDF ODIR-5K Polyp segmentation dataset

Metrics: ACC MF1 PSNR SSIM Dice

Baselines: FedAvg SCAFFOLD FedProx Ditto APFL FedRep LG-FedAvg MH-pFLID FedMD FedDF pFedDF DS-pFL

Builds on: FedAvg MH-pFLID Ditto FedRep

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