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Supportive Negatives Spectral Augmentation for Source-Free Cross-Domain Segmentation
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Proposes SNSA, which actively selects a few hard negative target fundus images for expert annotation and uses FFT amplitude-mixing spectral augmentation plus batch spectral shrinkage to adapt a source-free segmentation model.
Problem
Source-free domain adaptation for fundus optic disc and cup segmentation suffers from cross-domain shift, causing the adapted model to make wrong predictions on hard instances; annotation budgets are limited.
Approach
Select a few target-domain hard negatives via class-centroid cosine similarity of masked features, have experts annotate them, and augment them with multi-round Fourier amplitude mixing with unlabeled target images, combined with pseudo-label loss and batch spectral shrinkage.
Key results
- On Drishti-GS, average Dice 91.82% and ASSD 6.14 with full method in ablation (vs 90.47 / 7.01 baseline).
- On RIM-ONE-r3 optic disc, Dice 94.76% and ASSD 4.55 vs CBMT 93.36% and 6.20.
- On open compound setting, average Dice 88.98% vs PLPB 87.07% using only 4-5% annotated hard negatives.
Measured effects reported in the paper
| What was changed | Where | Measured | Effect |
|---|---|---|---|
| Use SNSA instead of CBMT | source-free fundus segmentation · Drishti-GS optic cup | Dice: 84.33 -> 86.54 | Helped |
| Select hard negatives with SNSA rather than SALAD | source-free sample selection · RIM-ONE-r3 | Avg ASSD: 6.92 -> 5.99 | Helped |
| Add spectral data augmentation (ablation) | SNSA on Drishti-GS · Drishti-GS | Avg Dice: 90.47 -> 91.18 | Helped |
| Add BSS loss (ablation) | SNSA with data augmentation on Drishti-GS · Drishti-GS | Avg Dice: 91.18 -> 91.82 | Helped |
| Add BSS loss (ablation) | SNSA with data augmentation on Drishti-GS · Drishti-GS | Avg ASSD: 6.71 -> 6.14 | Helped |
| Increase spectral augmentation rounds from 1 to 5 (ablation) | SNSA on Drishti-GS · Drishti-GS | Avg Dice | Helped |
| Vary λ; λ = 0.5 performs best (ablation) | SNSA on Drishti-GS · Drishti-GS | Avg Dice | Mixed |
Surprising findings
- Random selection of the same annotation budget performs comparably to the proposed selection on RIM-ONE-r3 (avg Dice 87.22 vs 87.30).
Limitations
- Hard-negative selection relies on source-model pseudo-labels and centroid similarity, which may be unreliable under strong shift.
- Requires expert annotation of a few target images, so it is not fully source-free and target-free of labels.
- Evaluated only on fundus optic disc/cup segmentation with a single source dataset.
Experimental setup
Datasets: REFUGE RIM-ONE-r3 Drishti-GS
Benchmarks: RIM-ONE-r3 Drishti-GS REFUGE val
Metrics: Dice ASSD
Baselines: DPL CBMT SFDA-FSM TT-SFDA TENT AdvEnt SRDA DAE BEAL PLPB SALAD OCDA
Builds on: Batch Spectral Shrinkage DeepLabv3+ DPL SALAD
Closest papers by meaning
- Understanding and Improving Source-free Domain Adaptation from a Theoretical Perspective (CVPR 2024 · similarity 0.85)
- AIF-SFDA: Autonomous Information Filter Driven Source-Free Domain Adaptation for Medical Image Segmentation (AAAI 2025 · similarity 0.85)
- A Unified Degradation-Robust Approach to SSL and UDA for 3D Medical Images (AAAI 2025 · similarity 0.85)
- SF(DA)$^2$: Source-free Domain Adaptation Through the Lens of Data Augmentation (ICLR 2024 · similarity 0.84)
- Learning Generalized Medical Image Segmentation from Decoupled Feature Queries (AAAI 2024 · similarity 0.83)
- Stable Neighbor Denoising for Source-free Domain Adaptive Segmentation (CVPR 2024 · similarity 0.83)
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