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Prompt-SID: Learning Structural Representation Prompt via Latent Diffusion for Single Image Denoising

AAAI 2025 · Image generation › Image restoration · approach: Diffusion priors for denoising and deblurring · 4 citations (OpenAlex)

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Proposes Prompt-SID, a self-supervised single-image denoiser that uses a latent-diffusion-generated structural representation as a prompt fused into a transformer denoiser via a structural attention module, trained on downsampled sub-image pairs with a scale replay mechanism.

Problem

Self-supervised single-image denoising via blind-spot networks or sub-image downsampling loses pixel information and destroys structural detail, and the scale gap between downsampled training images and original-resolution test images hurts performance.

Approach

A latent diffusion model (RG-Diff) generates a structural representation of the original-scale image conditioned on the sub-image representation; this representation is injected into a transformer denoiser through a structural attention module, and a scale replay branch without gradients enforces consistency at original scale.

Key results

Measured effects reported in the paper

What was changedWhereMeasuredEffect
Use Prompt-SID instead of N2CSynthetic denoising · Gaussian σ=25, KodakPSNR: 32.43 -> 32.41No clear effect
Use Prompt-SID instead of B2UPrompt-SID · SIDD BenchmarkPSNR: 50.79 -> 51.02Helped
Use Prompt-SID instead of N2CFluorescence imaging denoising · 1 HzSNR: 15.65 -> 15.89Helped
Use Prompt-SID instead of N2CFluorescence imaging denoising · 3 Hz and 10 HzSNR: 16.28 -> 15.98; 16.14 -> 16.06Hurt
Use Prompt-SID instead of B2UFluorescence imaging denoising · 30 HzSNR: 21.12 -> 21.10No clear effect
Add RG-Diff and SAM prompt fusion (ablation)Prompt-SID · SIDDPSNR: 51.32 -> 51.55Helped
Add RG-Diff and SAM prompt fusion (ablation)Prompt-SID · Kodak, Gaussian σ=25PSNR: 31.97 -> 32.41Helped
Add downsampled structural conditioning rather than Gaussian noise (ablation)RG-Diff · SIDDPSNR: 51.40 -> 51.55Helped
Add scale replay loss L_sc (ablation)Prompt-SID · SIDDPSNR: 50.97 -> 51.55Helped
Add scale replay loss L_sc (ablation)Prompt-SID · Kodak, Gaussian σ=25PSNR: 32.01 -> 32.41Helped
Add diffusion representation loss L_diff (ablation)Prompt-SID · SIDDPSNR: 51.03 -> 51.55Helped
Add diffusion representation loss L_diff (ablation)Prompt-SID · Kodak, Gaussian σ=25PSNR: 32.32 -> 32.41No clear effect

Surprising findings

Limitations

Experimental setup

Datasets: ILSVRC2012 SIDD-Medium SRDtrans two-photon calcium imaging dataset

Benchmarks: Kodak BSD300 Set14 SIDD benchmark SIDD validation fluorescence two-photon calcium imaging

Metrics: PSNR SSIM SNR

Baselines: N2C CBM3D N2V NBR2NBR B2U ZS-N2N DT

Builds on: Noise2Noise Noise2Void Blind2Unblind NBR2NBR ZS-N2N

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